250 ENDOCRINE GLANDS 



existed with a fat dystrophy, associated with polyuria 

 and polydypsia. 



2. -A certain number of obscure syndromes are classified 

 by certain writers among the pluriglandular syndromes. 

 Such are: bulbo-spinal myasthenia, improved by ovarian 

 pituitary organo therapy (A. Delille, Cl. Vincent). 



SCLERODERMIA associated with: 



(a) Melanodermia, due to thyroid ovarian insufficiency. 



(6) Exophthalmic goitre (Raymond). 



(c) Exophthalmic goitre and tetaiiy (Dupre and 

 Guillain). 



(d) Acromegalia. 



(e) Dercum's disease. It is, however, up to now 

 impossible to say for sure the exact nature of these 

 different associations. 



The conception of pluriglandular syndromes has a 

 practical interest: the application of mixed organo therapy 

 in their treatment. 



Renon has insisted on the successful results which may 

 be obtained by a mixed organo therapy which would fail 

 if only one gland was used. 



As an illustration, we will recall the use of thyroid 

 ovarian medication in ovarian insufficiency. In the same 

 manner, thyroid and testicular extracts can be used 

 in infantilism. It may be of interest to use the extract of 

 one gland, whose inhibitive action is known, on a certain 

 hypertrophied gland. It is in this manner that the 

 pituitary decreases the thyroid secretions and that pitu- 

 itary extract can be associated to the action of 

 dethyroided animal serums in the treatment of 

 Basedow's disease. 



