360 



ENDOCRINE GLANDS 



one of the internal secretions which we have been able to 

 determine so well. 



The preparation of the total extracts which, when all is 

 said, remains the best practical method of using these 

 products consists generally in the desiccation of the organ 

 previously crushed or made into a pulp. This desiccation 

 is done in a vacuum at a low temperature and is a rather 

 delicate procedure, considering how easily the organs are 

 affected. It must be carried out very rapidly and 

 Chamagne has shown that the toxicity of these products 

 increases in proportion with the time it takes to prepare 

 them. Certain manufacturers add a slight quantity of 

 antiseptic substances to assure proper keeping. These 

 products are usually prepared as powders in forms of 

 compressed tablets or in gelatine capsules. 



Next to these dried extracts and certain liquid prepara- 

 tions, such as the blood of animals having had their 

 thyroid removed, we must also mention glycerin extracts 

 of these substances which occasionally give excellent 

 results. In this way bone marrow, liver extract, etc., 

 are prepared. The preparation is made by macerating the 

 organ in glycerin. These same procedures have been 

 employed with alcohol, with oils and with ether, but they 

 are rarely used. Ether, however, extracts certain liquids 

 which might be of value in certain cases. (Iscovesco). 



THE ADMINISTRATION OF ORGANO THERA- 

 PEUTIC PRODUCTS. 



From what we have just said, we see that the most 

 common method of administration will be by mouth. 



These products can be administered diluted in fluids 

 or food; it is, however, essential that the temperature be 

 below 50 degrees C. This method of administration is 

 particularly useful in children. 



