364 ENDOCRINE GLANDS 



of the duodenum (secretin) acts on the secretion of pan- 

 creatic juice, and this juice, once secreted, finds in the 

 secretions of the intestines its activator (enterokinase) . 

 A mixture of duodenal extract and of pancreatic extract 

 is, therefore, a rational procedure. 



We have previously referred to associated insufficiencies 

 of several organs, particularly of several endocrine glands. 

 In these cases, it is perfectly legitimate to use several 

 extracts. It is possible to obtain preparations of different 

 extracts in the proportions in which they are best given. 

 It is also possible to alternate in giving various extracts, 

 for these substances act very slowly. It has also the 

 advantage of modifying each product as the case is being 

 treated according to the results. 



Sometimes it may be indicated to give two products 

 having an opposite action. Supposing we administer 

 pituitrin; this might cause hypof unction of a diseased 

 thyroid. In these cases, it may be necessary to administer 

 at the same time thyroid extract to prevent this. 



DOSES OF ORGANO THERAPEUTIC PRODUCTS. 



We are not going to give here the dose of each extract. 

 We are simply stating a few general principles. 



We have found that it is not necessary to divide our 

 doses into several portions each day. The action of these 

 products being very slow, it is not necessary to give small 

 repeated doses. 



We have already pointed out that these products, out- 

 side of a few preparations, are very easy to handle and for 

 this reason, doses can be varied according to the condition 

 of the patient and the results obtained. 



Physicians should remember that it takes a long time for 

 results to be noticed ; sometimes weeks go by before any 

 appreciable changes occur. This is said in order to avoid 



