ENDOCRINE THERAPEUTICS 



other hand, is conspicuous for a narrow strip of 

 cortex in its adrenal. Human beings possess a 

 cortex larger than that of any other animal. 



"No definite chemical substance has, as yet, been 

 isolated from the cortex. That remains a problem 

 for the investigator of the future. But certain 

 observations, especially concerning the relation 

 between the development and behaviour of the 

 so-called secondary sex characteristics, those 

 qualities of skin, hair, and fat distribution, 

 physical configuration and mental attitudes, which 

 distinguish the sexes, and the condition of the 

 gland, indicate clearly that an internal secretion 

 will be isolated, and that it will in its activity 

 furnish certain predictable features. 



"Three different layers of cells, arranged in 

 strings, that interpenetrate to form a network 

 directly bathed by blood, that breaks in upon them 

 from open blood-vessels, compose the cortex. 

 Most remarkable is this method of blood-supply, 

 for it is exceedingly common among invertebrates 

 and rare among the vertebrates. 



" In certain disturbances of these glands, especi- 

 ally when there are tumours, which supply a 

 massive dose of the secretion to the blood pre- 

 sumably, peculiar sex phenomena and general 

 development anomalies and irregularities are 



