92 ENDOCRINE THERAPEUTICS 



woman has no experience nor conception. I 

 have touched on this delicate subject because in 

 practical treatment by orchitic and ovarian 

 extracts it must be borne in mind. Both extracts 

 seem often to be most effectual on the opposite 

 sex. In that frequently occurring period of 

 mental depression that follows the climacteric, 

 orchitic extract works something like a revolution, 

 while ovarian extract completely fails. In many 

 of these women there is absolute sexual antipathy, 

 which the orchitic also removes. I think the 

 same rule applies also to men, viz. that ovarian 

 extract is a distinct nerve tonic, but here I do 

 not feel so sure of my ground. In the ovary we 

 have to deal practically with ovarian extracts 

 and those of corpus luteum. Below demonstrated 

 experimentally that ovarian extract, injected into 

 the blood stream, caused increase of blood- pressure, 

 increase of pulse frequency, increase of oxygen 

 intake, and increase of carbonic acid output. 



Extract of corpus luteum, on the other hand, 

 causes diminution of nitrogen excretion, diminu- 

 tion of oxygen absorption, increased activity of 

 the sweat glands, and a marked fall of blood- 

 pressure ; these differences form the basis of 

 our clinical applications. Preparations of whole 

 ovarian behave to some extent like those of the 



