PITUITARY 99 



whole sympathetic nervous system. His views 

 should be read and examined in his great work 

 Internal Secretions and Principles of Medicine. 



The extracts of the pars posterior physio- 

 logically and clinically behave so much like other 

 endocrine extracts that one can hardly doubt 

 the presence of an internal secretion. Sajous 

 looks on this as an extension of chromaffine 

 action, but distinct differences exist between this 

 and adrenalin which are difficult to explain ; 

 the pars nervosa may have an entirely nervous 

 role. Sajous says : " The marked advantage of 

 pituitary (meaning the pars posterior) is that it 

 sustains the rise of blood-pressure and is reliable 

 in shock and other emergency cases. It seems 

 also to sustain the temperature and the muscular 

 tone, cardiac, vascular, intestinal, and uterine, 

 longer than the adrenal active principle. It 

 possesses also a great practical advantage over 

 adrenalin in that it can be administered by the 

 mouth without compromising i'ts effects. More- 

 over, pituitary preparations have seemed to me 

 to produce the pharmaco-dynamic effects of 

 both the cortex and medulla of the adrenals." 

 Some observers have doubted the effect of pitui- 

 trin given by the mouth, but I feel sure that 

 Sajous is right on this point: the hormotones 



