ANTERIOR PITUITARY GLAND 103 



are the most definite signs. If the operation is 

 done before adolescence, there is a persistence of 

 sexual infantilism. The transplantation of the 

 organ from another animal, or injection of anterior 

 lobe extracts, prolongs life after extirpation, or 

 relieves the symptoms after partial extirpation. 



The work of Goetsch and Robertson has shown 

 conclusively that the development and proper 

 conservation of the genital functions cannot be 

 secured without the active assistance of the 

 anterior lobe secretion. 



Goetsch, of Chicago, again, says : " Perhaps 

 between no two of the ductless glands is a closer 

 inter-relationship in function more demonstrable 

 than between the pituitary and the sex glands. 

 We know from experiments in which the pituitary 

 gland has been partially removed in dogs, that a 

 deficiency in pituitary secretion thus produced 

 is followed by under- development, genital in- 

 activity, and hypoplasia in young animals, and 

 by impotence, sterility, and retrogressive changes 

 in the sex glands, together with adiposity, if the 

 animals were adult at the time of the operation. 



" It is the secretion of the anterior lobe which is 

 responsible for these sex changes. Clinical hyper- 

 pituitarism is well exemplified in the diseases, 

 gigantism, and acromegaly. In the early stages 



