io6 ENDOCRINE THERAPEUTICS 



and untreated ; these girls grow up sex failures. 

 Never advancing beyond rudimentary growth of 

 uterus and ovaries, they swell the ranks of the 

 disappointed, the sterile, and the nervous invalids. 

 They often begin to menstruate at 13 or 14, and 

 go on for a year perhaps, then comes irregularity 

 or complete cessation. This state of things, when 

 not due to manifest anaemia, points almost 

 conclusively to hypopituitarism, and can be 

 helped wonderfully by anterior pituitary medica- 

 tion. It should be given in good doses, 2 to 4 

 grains daily for two or three years, or till healthy 

 menstruation is well established. Under its 

 influence the pelvic organs develop as nature 

 demands. 



It is well known that children of both sexes 

 who have enuresis often get right under thyroid, 

 but there are failures also, and in these the 

 combination of pitglandin with thyroid will 

 often succeed. Failures of normal skeletal growth 

 and osseous development especially demand pit- 

 glandin. 



It should be an axiom, always in our minds, that 

 endocrine deficiency is very rarely single, and, 

 further, that the whole field must be considered 

 before we can expect success in treatment. 



Robertson, of Chicago, the discoverer of tethelin, 



