ANTERIOR PITUITARY GLAND 107 



his name for the active principle of the anterior 

 lobe, has published some suggestive observations 

 on the periods of life in which pitglandin has most 

 effect. There seems a short time, after lactation 

 has ceased, when the effect is one of retardation of 

 growth, but as the period of sexual maturity 

 draws near, there is rapid increase in growth and 

 probably hastening of maturity. This emphasizes 

 its value in the late years of girlhood. The life 

 of an imperfectly developed woman is often a 

 silent unsuspected tragedy. 



The further symptoms and effects of pitglandin 

 abnormality are thus graphically described by 

 Englebach, of St. Louis (Endocrinology, July- 

 September, 1920) : 



" The effect of the secretion from the anterior 

 lobe upon the muscular tonus is a subject which 

 has received comparatively little attention, but 

 which has appeared to the writer as being almost 

 as important as the difference present in the 

 osseous growth and development. This is par- 

 ticularly striking when one compares the muscular 

 development and tone of pre-adolescent hypo- 

 pituitarism (Lorain-Levi type) with those of 

 post-adolescent hyperpituitarism (acromegaly). 

 The extreme difference in the genital function 

 and development is also emphasized in comparing 



