122 JOH1ST T. HALSEY 



preceding secretion) pituitary headaches, the lat stages of acromegaly 

 (stage of hypof unction), tumors of the pituitary, epilepsy, and the psy- 

 choses of adolescence. 



Pituitary Headache. The frequency with which recurring headache 

 of a peculiar type (bitemporal, very intense, described by the sufferer as 

 "boring") was present in patients presenting other conditions suggestive 

 of pituitary disturbance, led Pardee to administer pituitary substance to a 

 series of seven such cases. The results obtained were most gratifying ; and 

 in all the cases making up this series there was marked amelioration 

 or cure of the headache. The dose employed by Pardee was a /4- to 2-grain 

 tablets 3 times a day by mouth. Glassberg reports that the daily ad- 

 ministration of 8 grains of pituitary extract cured severe headache of 

 over two years' duration in a patient presenting various signs of hypo- 

 pituitarism. Dalche reports relief of headache from administration of 

 0.1 gin. dried extract of the whole gland 2 to 4 times daily in a case in 

 which "an endocrin upset had induced congestion of the pituitary." 

 Timme and many others have noted that in many cases of dyspituitarism 

 relief of headache followed pituitary medication. 



Acromegaly. In acromegaly, when the disease has reached the stage 

 of hypopituitarism, benefit of some of the symptoms at least may be ex- 

 pected from the administration of whole gland preparations. Gushing (&) 

 (1912) cites one acromegalic who experienced in this stage subjective 

 benefit from the daily ingestion (for some months) of the enormous dosage 

 of 100 grs. of the whole gland preparation. Borchardt (&) states that 

 symptomatic relief has followed pituitary therapy in cases of acromegaly 

 which have been reported by a number of observers, although a still larger 

 number have failed to obtain such results. He quotes Renon and Delille 

 as reporting harmful effects in a case of acromegaly, which was evidently 

 still in the stage of hyperf unction. 



Tumors of the Pituitary. Examples of beneficial effects ascribed 

 to pituitary therapy, are 3 cases of pituitary disease with temporal neu- 

 ralgia and gradually increasing blindness reported by De Schweinitz and 

 1 Tow. In these cases administration of pituitary extract and thyroid com- 

 bined with mercury rubs 38 caused steady and progressive improvement of 

 vision. Elsberg and Krug also have reported a case showing signs of hypo- 

 physeal pressure, in which after failure of decompression, pituitary in- 

 jections improved the failing vision. 



Epilepsy. In epilepsy also good results have been reported from 

 pituitary administration, among others by Tucker (&) (1919). In sixty- 

 three out of two hundred consecutive cases, this author found what he 

 considered evidence of pituitary disease. After eliminating), thirty-five 

 of these because of other conditions, lie decided that twenty-eight of them 

 were cases of pure hypopituitary type, chronic or transitional, Adminis- 



3S In none of these cases were there other signs of syphilis. 



