OKGANOTHEKAPY AND HOBMONOTHEKAPY 123 



tration of 10 to 20 grains per diem of preparations of the whole gland 

 (to a few cases with high blood-pressure anterior gland only was given) 

 was followed by striking improvement in all but two cases. In the dis- 

 cussion of this report of Tucker's, Sterne stated that he had had no results 

 whatever from administration of anterior pituitary to a large number 

 of epileptics and that in several hundred cases of epilepsy treated by 

 administration of the whole gland the results had been nothing like those 

 reported by Tucker. Hoppe (b) saw no benefit from anterior pituitary 

 feeding in an epileptic considered by him to be a case of hypopituitarism. 

 In 1913, Gushing (c) reported that pituitary feeding ameliorated epileptic 

 attacks in two cases of dystrophia adiposogenitalis. 



A single case of apparent cure of epilepsy by the daily administration 

 of 8 to 10 grains of pituitary extract has been reported by Joughlin, and 

 Spears reports apparent cure following the administration of 2 grains of 

 anterior pituitary 3 times a day in a patient who from his sixth to his 

 twenty-eighth year had an average of four attacks per diem. 



While the examination of the skulls of epileptics by the X-ray is 

 stated by certain observers to show abnormalities of the sella in a large per- 

 centage of cases (McKennan, Johnson and Henniger ) , Munson reached 

 a different conclusion as the result of his investigations. There is 

 certainly no sufficient evidence so far that disease of the pituitary is the 

 general cause of epilepsy. In view, however, of the reported benefit from 

 pituitary therapy in epilepsy, it seems advisable to look for evidence of 

 pituitary dysfunction in epileptics, and when such is found to make a 

 trial of pituitary preparations. 



Psychoses of Adolescence. In the psychoses of adolescence Tucker (a) 

 (1918) reports beneficial effects from feeding preparations of the whole 

 gland or of its anterior portion. According to Ludlum and Corson-White, 

 pituitary therapy caused improvements in a group of cases, clinically 

 dementia prsecox of the hebephrenic type, but presenting signs of hypo- 

 pituitarism such as lowered blood-pressure, subnormal temperature, scanty 

 crines, undeveloped genitalia, muscular asthenia and adiposity. Angell 

 also reports (with no details) several good results from feeding whole 

 pituitary to several cases of dementia prsecox. 



It is regrettable that none of these authors give any details as to 

 dosage or duration of treatment and that Ludlum and Corson-White do 

 not state whether the preparations administered were those of the whole 

 gland or of the anterior or posterior portions. 



The Corpus Pineale 



While it is now generally conceded that the pineal gland is an organ 

 of internal secretion and that administration of pineal substance causes 

 in young animals acceleration of growth and sexual maturity (McCord 



