140 JOHN T. HALSEY 



and hypodeanic administration. For oral administration, the dosage rec- 

 ommended is 4 to 6 mg. per diem. According to personal observations 

 made on two transatlantic trips some years back, a proprietary remedy 

 containing epinephrin did not prevent, relieve, or cure seasickness in a 

 number of cases in which it was tried. 



The antispastic action of epinephrin justifies its use in stenosis of the 

 esophagus as recommended by Janowski. 



The favorable effect of suprarenal medication on the diarrhea of 

 Addison's disease, which has often been reported, may be due to this 

 inhibitory effect. Eppinger and v. Noorden have also found that enemata 

 (300 c.cm. of 1-150,000 adrenalin chlorid) are useful in the treatment of 

 the diarrheas of Graves' disease. Yukawa's observation that oral adminis- 

 tration of epinephrin increases the gastric secretion, suggesting its 

 employment in achylia gastrica and hypochlorhydria has been confirmed by 

 Loeper and Verpy, who also claim that in hypertonics it lessens spasm 

 while in hypotonics it increases the frequency and intensity of gastric 

 contraction. 



Empiric Therapy with Suprarenal Substances 



Suprarenal preparations have, like most other drugs, been used in the 

 treatment of a large number of different conditions, in most of which they 

 have proved of doubtful value or useless. 



Their use in various diseases of the bones, however, cannot be dis- 

 missed so summarily. In rickets they have been tried by a number of 

 clinicians, but the results have not been encouraging. In osteomalacia, a 

 considerable number of observers report favorable results ranging from 

 complete cure to marked improvement, while others report complete 

 failure. At present no definite conclusion can be reached as to the 

 efficiency of this treatment, but the results reported appear to justify 

 its trial ( Bossi (a) (b) (<"), Novak, Cristofoletti). Bossi, the originator of 

 this method of treatment, advises the hypodermic administration of 0.5 to 

 1.0 e.cin. of the 1-1,000 solution once or twice daily, every 10 or 12 days, 

 stopping treatment for one or two days. Too early cessation of treat- 

 ment has been followed by relapse in cases which had reacted favorably. 

 Cristofoletti concludes that this method of treatment is more likely 

 to prove successful in the osteomalacia of pregnant women than in other 

 cases. 



Epinephrin and the Arsenical Antisyphilitic Preparations. In 1914 

 Mi Han reported that certain of the disagreeable effects following the ad- 

 ministration of the arsenical antiluetics could be obviated by the use of 

 epinephrin. In a more recent publication, he advocates as a routine 

 measure the oral administration of 2 mg. (2 c.cm. 1-1,000 sol.) 1 hour be- 

 fore the injection of the salvarsan, repeating this 5 minutes before and 1 



