158 EMIL NOVAK 



often centres the vomiting promptly, in cases in which intramuscular use 

 has failed." 



The dosage of the corpus luteum extract for the control of the nausea 

 of pregnancy varies with the severity of the case. In the milder cases 

 Hirst advises giving 2 c.c. daily, and in the pernicious cases the same 

 amount may be given even twice daily. With these amounts unpleasant 

 reactions are said not to occur. 



On the whole, it must be evident that there is no real scientific basis 

 for the form of treatment recommended by Hirst. I am frank to say that 

 the results in my hands have not been as brilliant as those which Hirst 

 reports. Rongy and others likewise have reported disappointing results 

 from this method, and it remains to be seen whether it will ultimately 

 achieve a place for itself in the treatment of the nausea, of pregnancy. 



Ovarian Therapy in Neurological Practice. Climenko has reported 

 good results from the use of corpus luteum extract in the treatment of 

 various mental disorders. He mentions especially a case of "menstrua- 

 tion insanity" of the type 1 described by Kraft-Ebing and a case of mild 

 manic-depressive insanity. The results in a patient with hysteria, asso- 

 ciated with "mechanical obstruction" of the uterus, were questionable. 

 Several other cases are cited as illustrating the possible value of corpus 

 luteum extract in the treatment of female neurological and psychiatric 

 practice, but on the whole the evidence brought forth is rather unim- 

 pressive. The same statement may be made as to the treatment of epilepsy 

 by ovarian extracts. Cases have been reported in which good results are 

 said to have been observed, as in the three patients treated by Ashe, but 

 the empiricism of such medication is obvious, and its results are probably 

 of no great value. 



Ovarian Therapy in Climacteric Hypertension. Hopkins has re- 

 cently reported a series of fifty-one cases of hypertension occurring in 

 women at the time of, or just after, the menopause. He presents evidence 

 which he believes indicates that these cases are unlike the ordinary 

 cases of high blood pressure in men at the corresponding age, and explains 

 them as due to the withdrawal "of at least a part of the secretion of the 

 ovary" at the menopause. He suggests the designation of "endocrinal 

 hypertension" for these cases, which he looks upon as of relatively benign 

 type. In addition to the general regime customary in hypertension cases, 

 he advocates the giving of corpus luteum, especially by the hypodermic 

 method. 



Ovarian Therapy in Sterility and Dysmenorrhea. Ovarian and 



corpus Intenni extracts have been used in the treatment of sterility, though 

 with, rather indifferent results. Fallenberg advocates large doses of the 

 extracts, beo-innino- with five grains a day and gradually increasing until 

 at the end of a month 30 grains a day is being taken. The treatment 

 should be continued for one year. Solomons believes that the most 



sue- 



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