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blood supply and stroma they conform to those prevailing in the gland 

 as a whole. They react with iodin. (See Figs. 22, 23, 24.) 



Intermediate Adenomas. These tumors are usually multiple and 

 on section quite distinct in appearance from the non-tumor thyroid. 

 They share the same variations in size and number that simple adenomas 

 do but have well formed fibrous capsules. Historically they are com- 

 posed of less differentiated and more closely packed alveoli, less stroma, less 

 colloid and while they react with iodin it is slower and to a less degree than 

 with simple adenomas. (See Figs. 25, 26.) Michaud, Miiller, W. (a). 



Fetal Adenomas. These are the best known and the most distinctive 



Fig. 23. Simple adenoma, colloid phase. (After Marine, J. Med. Research, 1913: 



typos of benign tumors. They are usually multiple and when their growth 

 is arrested early may persist with but little change into old age. In gross 

 appearance the smaller adenomas may be indistinguishable from large 

 lymph foci that may be present. The larger tumors are round in form and 

 in the developmental stage are grayish-opaque in color. The tumor issue is 

 friable, very cellular, and there is no visible colloid. (See Figs. 27, 28, 29.) 

 Billroth, Berard and Alamartine, Bloodgood (&), Delore, Goetsch (a). 



To summarize the major features of the three arbitrary groups, it is 

 found that all have true capsules often rudimentary in simple adenomas 

 and progressively more prominent and distinct in the intermediate and 

 fetal groups. The stroma is poorly developed and scanty in all, being 

 least developed in the fetal adenomas. No trabecula? are present, hence no 

 lobulation as in the normal thyroid. The larger well formed vessels lie 

 in the capsules, while those of the parenchyma have poorly developed 

 muscular and adventitial coats. These tumors grow from the subcapsular 



