HYPOTIIYROIDISM 393 



themselves depend on a normal supply of the thyroid hormone. Again 

 these degenerative changes may be due to the same noxus which determined 

 the atrophy of the thyroid. At times the lesions observed are hypertrophic 

 in nature and have been regarded as compensating for the loss of thyroid 

 function. They may, however, be ascribed as well to an irritative toxic 

 reaction such as caused the original thyroid ( hyperplasia. 



A B 



Fig. 1. Sporadic cretinism with acromegaiy. (N. W. Janney, original observa- 

 tion. ) 



The parathyroid glands may undergo fibrosis and atrophy of the gland- 

 ular cells (Victor Horsley (i), Forsyth (&)). Vesical and colloid forma- 

 tion have been reported by Forsyth and Kojima. 



The pituitary regularly hypertrophies in animals after thyroidectomy 

 and sometimes in myxedema (various observers). Mott noted that the 

 pars nervosa was encroached upon by overgrowth of the pars intermedia 

 in hypothyroidism of the psychic type. Schonemann, however, quoted 

 by Crotti, reported that of 112 cases of goiter the hypophysis was atrophied 



