PHAEMACOLOGY OF HYPOPHYSEAL EXTRACTS 745 



within ten days. She used 100 mg. as the daily dose divided between the 

 two methods of administration. Experimental endeavors to inhibit the 

 progress of tuberculosis in guinea-pigs by the injection of tethelin have so 

 far been unsuccessful. Corper (1915) got no effect either in the duration 

 of life, development, recession or rupture of the intracutaneous tubercles 

 produced by dead human bacilli. 



Effects of Anterior Lobe on Metabolism. The studies of the effects 

 of the administration of the anterior lobe of the hypophysis on metabolism 

 are few and contradictory. Malcolm (1904) found that the desiccated 

 substance caused a nitrogen retention and an increased calcium output, 

 while White and Titcomb (1914) reported a lesser calcium and phosphorus 

 urinary content under similar conditions, and Titcomb (1913-14) ob- 



Fig. 1. Showing the drop in arterial pressure induced by the injection of an ex- 

 tract of the anterior lobe of the hypophysis. (After Hamburger, Am. J. Physiol.) 



served an increased calcium and phosphorus excretion in cancer patients 

 as a result of the administration of anterior lobe substance. Hewitt (a) (&) 

 (1915) concluded that the administration of small amounts of pars 

 anterior of the ox together with thyroid tissue has little if any influence 

 on the action of the thyroid as given alone. 



Pharmacodynamic Effects of Anterior Lobe Extracts. The effects 

 of extracts of the anterior lobe on blood-pressure in moderate doses are 

 generally minor in degree and tend towards a transient lowering as shown 

 by Halliburton, Candler & Sikes (1909). A similar effect was demon- 

 strated to follow tethelin injections by Robertson (1916). Howell(&) 

 (1898) early showed that the pressor effect was not obtained from this por- 

 tion of the hypophysis, and his results have been amply confirmed. On the 

 other hand, Hamburger (a) (&) (1904) found that when saline extracts of 

 the anterior lobe are intravenously injected they produce a decided fall in 

 pressure, accompanied by an acceleration and weakening of the heart-beat. 

 He confirmed these observations in 1910 and considers that his decidedly 

 positive results as opposed to the negative ones of Oliver and Schafer 

 (1895) are due to the fact that these workers destroyed the depressor sub- 

 stance by their method of preparation of the extract, This is supported by 



