PHARMACOLOGY OF HYPOPHYSEAL EXTRACTS 765 



effect on the smooth musculature of the gland. With this Bell (6) (1919) 

 is inclined to agree. 



The studies of the comparative action of posterior lobe extract with 

 other drugs have been many, but those concerned with ergotoxin and 

 epinephrin are of greatest interest. Frohlich and Pick (6) (1913) ob- 

 served that posterior lobe extracts exerted an antagonistic action on the 

 effects produced by ergotoxin and this was confirmed by Cow (1919). 

 Dale (1909) concluded from his studies that epinephrin and the effective 

 principles of posterior lobe extracts are two different substances. Houssay 

 (e) (1915-16), Cow(c) (1919) and others have adduced evidence support- 

 ing this idea, the former considering that the activity of epinephrin is 

 antagonistic and never synergistic to that of posterior lobe extracts. This 

 is supported by the observations of Githens and Meltzer (1916). 



