788 J. P. SIMONDS 



Miscellaneous Lesions of the Hypophysis 



4 



Localized accumulations of lymphocytes are occasionally seen in the 

 hypophysis. They are mentioned by Simmonds(e). Pirone(c) observed 

 round cell infiltration in the neurohypophysis in hydrophobia, Berblinger 

 (a) found large accumulations of lymphocytes about a sarcoma which had 

 invaded the posterior lobe through the infundibulum from the brain. Such 

 cells are also abundant about tuberculous and syphilitic lesions of the hy- 



iwf 





Fig. 4. Aroa of hmphocvtic infiltration in the middle lobe of the hypophysis. 

 Magnified 130 times. 



pephysis. In two hypophyses which I have studied there were groups of 

 lymphocytes immediately behind the pars intermedia. .(See Fig. 4.) 

 One of these hypophyses was from a man who died of chronic diffuse 

 nephritis ; the other from a colored male who succumbed to hemorrhagic 

 (lethargic) encephalitis. In the latter case there was also a slight degree 

 of perivascular round cell infiltration in the neurohypophysis similar to 

 that seen in the brain. These localized accumulations of lymphocytes in 

 the hypophysis suggest the similar aggregations so commonly found in 

 the thyroid gland is exophthalmic goiter. Their significance in the hy- 

 pophysis is not clear, except possibly in the case of encephalitis. 



Schmorl noted lenkemic infiltration of the hypophysis similar to 

 that seen in the liver and kidneys in leukemia. 



Simmonds(e) mentions finding abnormal islands of epithelium in the 



