800 



J. P. SIMONDS 



to which have been especially emphasized by Ehlers. They are dis- 

 tinctly squamous cell tumors. The peripheral cells, both of the cysts and 

 of the solid masses, that is, the cells which rest upon the basement mem- 

 brane, are columnar like those cells composing the columnar cell layer 

 of the skin and mucous membrane of the mouth. In the deeper layers, 

 the cells show the connecting bridges "prickle cells" of the stratum 

 spinosum of the mucous membrane of the mouth and the skin. True 

 cornification does not occur, although hyaline degeneration of the central 



parts of some of the 

 masses may give rise to 

 structures which some- 

 what resemble epithelial 

 "pearls." The absence 

 of cornification is a 

 characteristic, which, ac- 

 cording to Erdheim(&), 

 differentiates these tu- 

 mors sharply from cho- 

 lesteatomas that may 

 originate in the same 

 region, but whose origin 

 is not connected with 

 the hypophysis. 



Craniophar- 

 yngeal duct tumors are 



/ o 



very frequently accom- 

 panied by Froelich's 

 syndrome. In the series 

 which I have collected, 

 this symptom complex 

 was present in 14 out of some 34 cases in which a statement was made con- 

 cerning its presence or absence. 



Endothelioma. Seven cases diagnosed as endothelioma of the hy- 

 pophysis have been found in the literature, including a tumor reported by 

 Wolf as a cylindroraa. It is not clear in all cases whether the tumor 

 actually originated in the hypophysis or invaded the gland. In Zak's case 

 the hypophysis was intact but compressed by the tumor. In those of 

 Rennie and Mullaly(6) the hypophysis had been almost completely re- 

 placed by the new growth. Schoenemann records a case of lymphangioma 

 of the hypophysis which is contrary to Thaon's(>) view that the hypophysis 

 is lacking in lymph vessels, if, indeed, Schoenemann's tumor actually orig- 

 inated in (he gland. 



Diagnosis of perithelioma has been found seven times. Only those of 

 Jacksou(r/) and of Kon(fc) are described with sufficient clearness. 



Fig. !). Craniopharyngeal Duct Tumor (Erdheim). 

 ]\Ia<iiiiiic(l 110 times. Reproduced from article by Dr. 

 Harry Jackson, Jour. Amer. Med. Assn., 1916, lxvi/1082. 



