PATHOLOGICAL ANATOMY AND HISTOLOGY 801 



Kraus(c) mentions "perithelioma-like structures" in two hypophyses which 

 also contained adenomas. The peritheliomas described by Jackson and by 

 Kon were characterized by masses of cells with small round nuclei, 

 arranged around blood vessels from which they were separated by a narrow 

 hyaline zone. 



Psammomas of the hypophysis have been recorded by Woollcombe and 

 by Windenberg. 



Teratomas, closely associated with the hypophysis, have been reported 

 nine times. These have usually contained bone, cartilage, connective 

 tissue, and, sometimes, squamous epithelium. White found a teratoma of 

 the hypophysis containing medullated nerve fibers, striated muscle, con- 

 nective tissue, fat, and a structure resembling a sympathetic ganglion. 



Tumors of the Pars Intermedia. These are very rare. Boyce and 

 Beadles (6) found, somewhat accidentally in the routine examination of hy- 

 pophyses, a small mass on the infundibulum, having the structure of the 

 middle lobe of the hypophysis. There were no symptoms that could be 

 ascribed to the presence of the tumor. Erdheim(fr) observed a similar 

 mass the size of a hemp seed in the infundibulum. A tumor at the base of 

 the brain described by Cushing(6), compressed the anterior lobe of the hy- 

 pophysis, and was composed of vesicles containing colloid. There was 

 undoubted evidence that the tumor originated from the pars intermedia. 

 Schmorl found a. distinct hyperplasia of the middle lobe in a case of 

 myxedema. Weichselbaum found a group of colloid cysts lined with 

 ciliated epithelium in the back part of the anterior lobe. 



Rare Tumors of the Hypophysis. A lipoma of the posterior lobe 

 has been described by Weichselbaum. Arnold (&) reported a lymphad- 

 enoma of the anterior lobe in a patient with acromegaly. Stains to show 

 granules were not used, and it may be justly questioned whether this was 

 not in reality a struma pituitaria. Gliomas of the neurohypophysis have 

 been recorded by Nonne(6), Hilario, and Burr. 



Erdheim(d) has described a remarkable tumor, composed of eosinophil 

 cells like those of the anterior lobe of the hypophysis, and occupying the 

 sphenoidal sinus. The hypophysis was in its usual position in the sella 

 turcica and was normal in appearance. The patient was acromegalic. 

 Leegaard removed at operation a large soft tumor from the roof of the 

 pharynx. Histologically, the growth resembled the anterior lobe of the 

 hypophysis, and probably developed from rests of the "hypophysis pha- 

 ryngea." It is possible that in cases of acromegaly with normal hy- 

 pophyses, exploration of the sphenoidal sinuses and of the vault of the 

 pharynx, might reveal a tumor composed of hypophyseal cells. 



Metastatic Tumors of the Hypophysis. Metastatic tumors in this 

 organ are not common. In 1,500 necropsies of all kinds Simmonds(/) ob- 

 served this lesion 17 times. In 40 cases of carcinoma that came to 

 autopsy FraenkelO) found metastases in the hypophysis twice. In 20 



