DYSTROPHIA ADIPOSOGENITALIS 863 



tan Halberstadt '03, Zak '04, and two of his own). However, he did not 

 mention Berger's which was similar to Frohlich's, and which was re- 

 ported soon after the latter published his case. Uhthoff (6) (1915) collected 

 forty-four cases with affection of the pituitary, chiefly tumors, which ap- 

 peared in the literature prior to 1886, the year in which Pierre Marie 

 described the syndrome of acromegaly. From this period to the time of 

 the report of Frohlich's case (1901) pituitary tumors were roughly classi- 

 fied into two groups, those with symptoms of acromegaly and those with- 

 out symptoms of acromegaly. There was apparently considerable con- 

 fusion as to the nomenclature until Bartels(fr) (1908) suggested the term 

 dystrophia adiposogenitalis. Hitherto the vast majority of cases of pitu- 

 itary disease were reported as acromegaly. Since then hypcpituitary states 

 dystrophia adiposogenatalis, pituitary infantalism, cachexia hypophyso- 

 priva have been more generally discussed. Uhthoff (&) later collected 

 three hundred and twenty-eight cases of pituitary disease reported prior to 

 1911, including the forty-four above mentioned. Of thc'&e two hundred 

 and seven presented symptoms of acromegaly and one hundred and twenty- 

 one were without -symptoms of acromegaly. 



At a meeting of the Ophthalmological Society of the United King- 

 dom in 1887 long before the syndrome dystrophia adiposogenitalis was 

 recognized there occurred a remarkable discussion on the subject of 

 pituitary lesions in their relation to the eye symptoms, obesity, menstrual 

 disturbances and mental manifestations. The following is quoted from 

 the proceedings of this meeting published in the British Medical Journal, 

 Vol. I, 1887, p. 1334. 



Mr. J. B. Story (Dublin) read an account of the case of a young wom- 

 an who gradually became blind in the right eye, and had temporal hemian- 

 opsia in the other eye. She suffered from headache and slightly from 

 vomiting. One of the things she complained most of was drowsiness about 

 midday each day. It was noticed that she got much stouter. She also 

 suffered from irregular menstruation. At the time of reporting the case 

 she was in fair general health, and able to follow her occupation (that of 

 a dressmaker). Mr. Nettleship remarked that a very similar case had 

 been recorded in the Society's Transactions, and in that instance, after 

 death, a tumor was found in the pituitary fossa. Other similar cases 

 had been published, and he had lately seen a case at St. Thomas's Hospital 

 where the same train of symptoms had been produced in the same way.- 

 Dr. Hill Griffith said that he had placed on record a case identical with that 

 of Mr. Story. Cessation of menstruation and sleepiness had been present 

 in his case; and, in several cases that he had seen, the patients had com- 

 plained of getting stout. Dr. James Anderson briefly described the case 

 he had published, which closely agreed with that of Mr. Story. He said 

 that it was the rule in pituitary tumors that the patient should get very 

 stout. Dr, Coupland mentioned also the concurrence of an increased 



