DYSTEOPHIA ADIPOSOGENITALIS 865 



The increased carbohydrate tolerance, studied by Goetsch, Gushing 

 and Jacobson, and the low blood pressure, symptoms of posterior lobe 

 deficiency, they were able to relieve by injection of infundibulum. 



W. Blair Bell (6) in some recent animal experimentation, was unable to 

 produce the syndrome of dystrophia adiposogenitalis by the partial re- 

 moval of the pars anterior, although it followed compression and separa- 

 tion of the stalk; however, in both instances the genital syndrome de- 

 veloped. 



Pituitary Feeding 



For a complete and up-to-date bibliography on the effect of pituitary 

 feeding the reader is referred to the admirable article of Hoskins and 

 Hoskins (1920), Endocrinology, Vol. IV, No. 1, p. 30. After a care- 

 ful analysis of the results obtained by many investigators, including their 

 own studies, they make the following statement: "From 1897-1916 

 there was about an even division of opinion as to whether pituitary feeding 

 would or would not give positive results, but since then most of the papers 

 published on the subject agree that at least with the feeding of the anterior 

 lobe of the hypophysis a definite stimulation of growth can be produced. 

 This has been claimed for protozoa (Flatcher '19), worms (Wulsen '16), 

 birds (Winternitz '16 opposed by Pearl '16) and mammals (Kobertson 

 'IT and Marinus '19)." 



Goetsch (a) ('16) made extensive investigations on the effect of pitui- 

 tary feeding upon growth and sexual development in rats. Feeding of the 

 anterior lobe extract caused increased weight and greater and more vig- 

 orous body growth and development over the control. The period of 

 complete sexual development is shortened by at least one-third of its nor- 

 mal time, and the sexual instincts are early awakened. The posterior lobe 

 extract causes failure to gain in weight, loss of appetite, increased peri- 

 stalsis, muscular tremors and weakness in the hind legs. 



Grafting. Numerous attempts to transplant the hypophysis with 

 the aim of increasing functional activity have met with failure. Schaefer 

 repeatedly implanted the whole organ or small portions into the tissues 

 of white rats, rabbits, and guinea pigs without satisfactory results. 



Exner states that he was able to observe a temporary increase of growth 

 in non-hypophysectomized rats over their controls, in which he implanted 

 an extra pituitary. 



Crowe, Gushing and Homans(^) were able to prolong the life of the 

 dogs in which the whole gland was extirpated, but they were unable to save 

 them. They admitted that the results may have been due to absorption 

 of the secretions contained in the implanted gland. However, a successful 

 graft from the pituitary of a child dying in childbirth was made by Gush- 

 ing^) in a man suffering from destruction of the gland through cystic de- 



