880 HAEVEY G. BECK 



clinoid processes, presented marked symptoms of diabetes insipidus and 

 adiposogenital dystrophy. 



The unique case reported by Maranon and Rosique is of great clinical 

 interest. A boy, who received an accidental bullet wound in the mid- 

 frontal region, showed no nervous or mental symptoms, but later de- 

 veloped all the signs of Frb'hlich's syndrome together with severe dia- 

 betes insipidus. An attempt to remove the bullet proved fatal. At post- 

 mortem the bullet was found in the region of the infundibulum, the stalk 

 of the pituitary body being interrupted by the cicatricial tissue formed 

 around the bullet. The pituitary itself was quite unharmed. The authors 

 maintain that the occurrence of diabetes insipidus was the result of block- 

 ing of the canal in the stalk of the infundibulum. 



Cachexia Hypophysopriva 



During the earlier experimental studies of the pituitary it was ob- 

 served (Vassale and Sacchi: Paulesco(fr)) that a peculiar train of symp- 

 toms followed within a few days after the complete removal of the gland in 

 animals. Among the symptoms enumerated were tremors, fibrillary twitch- 

 ings, arching of the back, insensitiveness, diminution in pulse and respira- 

 tory rate, fall in temperature, apathy, coma and death. These acute 

 symptoms and death do not occur if a small viable portion of the anterior 

 lobe is allowed to remain (Paulesco(&) ). The immediate transplantation 

 of the removed gland, or subcutaneous injection or feeding of anterior lobe 

 will also prevent a threatened cachexia hypophysopriva (Gushing, et al.). 

 The condition has been observed clinically autopsies showing either a 

 complete destruction of the gland or of the entire anterior lobe (Sim- 

 monds (m), Fraenkl 



Adenoids and Pituitary Deficiency 



A relation between adenoid growth and hypopituitary states has been 

 suggested, and cases have been cited of hypophyseal feminism, the cause 

 of which was attributed to adenoids. This view is based on the discovery 

 by Erdheim(&) (1904) of a small epithelial body situated behind the alae 

 of the vomer, which has been designated "Hypophysis pharangea." It 

 is a part of the hypophyseal system, representing the lowermost extremity 

 of Rathke's pouch and resembles in its histological structure the glandular 

 lobe of the pituitary. 



Bryant considers that chronic nasopharyngeal infections interfere with 

 pharyngeal pituitary function, and that the removal of tonsils or adenoids, 

 which tend to relieve the chronic infection, result in more rapid growth and 

 improved nutrition. Leegaard reported a case of retropharyngeal tumor 

 of hypophyseal structure. 



