DYSTEOPHIA ADIPOSOGENITALIS 9U 



A. Anterior lobe deficiency. 



1. Disturbance of growth (skeletal defects) 



2. Development of obesity (hypophyseal fat dystrophy) 



3. Gemtal hypoplasia (infantile genitalia) 



4. Temperature anomalies (hypothermia) 



5. Cachexia hypophysopriva (apituitarism) 



B. Posterior lobe deficiency. 



1. Hypotension 



2. Increased sugar tolerance 



3. Diminution of basal metabolism 



4. Asthenia 



Associated Symptoms the result of hypophyseal tumors include 

 headache, vertigo, vomiting, visual defects, nervous and mental disturb- 

 ances, and polyuria or diabetes insipidus. The latter, which was formerly 

 attributed to posterior lobe deficiency, is not included in that group, ow- 

 ing to the result of the clinical and experimental investigations of Houssay, 

 Leschke, and others previously mentioned. 



Organotherapy. Most of the symptoms of dystrophia adiposogeni- 

 talis, unless due to a progressive neoplastic growth, are favorably influ- 

 enced by the administration of the hormones of the pituitary, thyroid and 

 the gonads. The thyroid hormone is equally as important, if not more 

 so than the pituitary. The ovarian and testicular have the least therapeu- 

 tic effect. 



The thyroid has been called a sex gland because of its accelerating in- 

 fluence on the function of the sexual organs. The presence of the thyroid 

 hormone, as well as that of the pituitary, is essential to the normal 

 development and function of the gonads. Moreover, it is the greatest 

 stimulator of metabolism known, acting probably as a general protoplasmic 

 stimulant. The thyroid also stimulates the pituitary function. It is 

 thus easily conceivable how the administration of thyroid gland sub- 

 stance would favorably influence the various groups of symptoms due to 

 pituitary deficiency in dystrophia adiposogenitalis. 



Through its influence on metabolism it has a tendency to improve 

 the fat dystrophy, decrease sugar tolerance and increase the rate of basal 

 metabolism. The increased basal metabolic rate tends to restore the hypo- 

 thermia, bradycardia, hypotension, dry skin, etc., to normal. Its ac- 

 celerating influence on the functions of the pituitary and sex glands aug- 

 ment the effect of pituitary and ovarian gland substance upon genital hypo- 

 plasia and hypogonadism as well as on infantilism of hypophyseal origin. 



The experimental production in animals of a syndrome correspond- 

 ing to Frohlich's by an almost complete extirpation of the anterior lobe 

 of the pituitary, and the possibility of preventing the development of 



