922 HAKVEY G. BECK 



Schweinitz and How) and by pituitary, thyroid and suprarenal gland 

 substance (Timme(6)). 



For the relief of pdtuitary headache Pardee recommends the whole 

 gland in doses of one-half to two grains three times a day, decreasing the 

 dose as the headache is relieved. The cachexia which follows destructive 

 lesions of the anterior lobe is favorably influenced by pituitary feeding, 

 especially with the anterior pituitary extract. Occasionally the most an- 

 noying symptoms of dystrophia adiposogenitalis are polydipsia and 

 polyuria due to an associated diabetes insipidus. The condition may be 

 transitory, although it is usually permanent. However, the symptoms can 

 be controlled by systematic administration of posterior lobe extract "pitui- 

 trin" in 0.51 c.c, doses hypodermically. This dose ordinarily controls 

 the thirst and polyuria from one to two days. The same dose given per 

 rectum controls the polyuria for three or four hours (Goetsch). The re- 

 markable effect of "pituitrin" in case XV, Series 1, upon the urinary 

 output is shown in Figure 22. For further information on this subject the 

 reader is referred to the chapter on Diabetes Insipidus. 



The effect of anterior lobe feeding upon growth has been emphasized 

 (Goetsch, Gushing, etc.) and Beverly Tucker reported the case of an 

 underdeveloped boy, who grew % of an inch in five weeks on pituitary 

 feeding. 



The dose of liquid extract of the posterior lobe and infundibulum 

 (infundibulin, pituitrin) because of its wide range of therapeutic ap- 

 plication has become fairly well established; ordinarily 0.5 to 1 c.c. admin- 

 istered hypodermically, constitutes a dose, although larger doses are not 

 infrequently given. The development of intestinal cramp indicates its 

 physiological limits. Larger doses will produce tachycardia, tremors, 

 etc. 



Powdered whole gland may be given in doses ranging two to six grains 

 daily. Both posterior and whole gland substance are contraindicated 

 in conditions of high blood pressure, because of the pressor action of a 

 principle contained in the posterior lobe and infundibulum. 



X-Ray. Although Gramegna (1909) reported a case of acromegaly 

 treated by X-ray, in which the headache was relieved and the visual fields 

 temporarily improved, the subject did not receive general recognition 

 until Beclere (1913) reported four cases in which radiotherapy met with 

 considerable success. In one of his cases headache, dizzines, nausea and 

 vomiting disappeared and the vision improved; the pathologic process 

 in the bones was arrested and the sexual function restored; five years 

 later the patient was reported in good health. In all of his cases there was 

 improvement of the visual fields and in two the headaches completely 

 disappeared. 



Others including Calamet, Terrien, Loeb, Barrier, Jaugeas(a) and 

 Schafer(a) have reported cases treated with practically the same results. 



