952 



IKDEX 



Internal secretions, history of, experi- 

 ment of, Minkowski, Oscar (1889), 

 producing experimental diabetes by 

 excision of pancreas, 63. 



pineal gland, extirpation and 



feeding and injection experiments, 

 68. 



removal of pituitary body, par- 

 tial and total, 65. 



first crude elements of therapy of, 

 47, 48. 



first discovery regarding effects of 

 absence of thyroid body, 52. 



first experiment in physiological 

 surgery upon human beings, 66. 



first half of nineteenth century, 

 57. 



function first stated clearly by 



Theophile de Bordeu (1722-76), 46. 



glycogenic secretion in animals, 

 58. 



hormonic equilibrium of body and 

 thermodynamic equilibrium, 76. 



investigations and treatises on, 77, 

 78. 



lungs or individual cells of body 



tissues provisionally regarded as 

 ductless glands, 58. 



myxedema, 53. 



observations of Claude Bernard, 

 epoch-making character as indicated 

 by Sir Michael Foster, 60. 



Claude Bernard (1843), intro- 

 ducing new concept of, 58. 



Brown-Sequard an old Bordeu 

 theory of (1893), 62. 



chromaffin system, epinephrin, 

 68. 



chromaphil system, 68. 



endemic goiter, in antiquity, 

 50. 



giants and dwarfs, 49. 

 -Legallois (1801), 57. 



ovariotomy and Battey's opera- 

 tion, 66, 67. 



pineal gland or epiphysis cere- 

 bri, 67. 



doctrine of "macrogenito- 

 somia precox," 67. 



experimental extirpation of, 

 68. 



pituitary body, activities of, 

 66. 



discovery of extract of pos- 

 terior lobe (pituitrin), 66. 



perverted function of gland, 

 "dyspituitarism," 66. 



structure of, 64. 



Internal secretions, history of, observa- 

 tions of Claude Bernard, placental 

 internal secretion, 68. 



Plater, Felix (1614), in connec- 

 tion with doctrine of the "status 

 thymicolymphaticus," 50. 



relation of tetany to thyroidec- 



tomy and parathyroidectomy, 64. 



thyroidectomy, 60, 61. 



obtaining of glycogenic substance 



from liver in the form of a dry pow- 

 der, which could be converted into 

 dextrose by fermentation, Claude 

 Bernard (1855), 59. 



pernicious anemia, 54. 



"pluriglandular insufficiency," in- 

 troduced by Claude and Gougerot 

 (1907-8), 69. 



pouring out of thyroidal and ad- 

 renal secretions under surgical shock 

 or passion or fear, 55. 



relations of, to tonus of nervous 



system, 73, 74, 75. 



tetany, 53. 



thymus gland, 55. 



treatment of myxedema by thy- 

 roid extract, 61. 



hormones, 4, 5. 



nature of, 8. 



terminology of, 5. 



nature of, bodily reactions to circu- 

 lating chemical substances, 7. 



carbon dioxid, 7. 



differentiated from ordinary se- 

 cretory products of gland-cell activ- 

 ity, 8. 



from other specific substances 

 in blood, 9. 



epinephrin, 8. 



hormones, 8. 



secretin, 7. 



parhormones, 8. 



relation of, to tonus of nervous sys- 

 tem, 73, 74, 75. 



terminology of, 3, 4. 



theory of, definition of, 45. 

 history of, 45. 



Interreiial system, overfunction of, 

 69. 



Interstitial injury, as method of creat- 

 ing gland deficiency, 41. 



Intestinal antiseptics, in cretinic de- 

 generation, 472. 



Intestinal hemorrhage, vasocons-trictor 

 action of epinephrin in, 137. 



Intestinal mucosa, immunity to re- 

 peated administrations of extract of, 

 31. 



