PATHOLOGICAL CONSIDERATIONS OF THE PINEAL 39 



to the pineal eye component of the pineal body complex to which general 

 hypothesis Marburg (1907) gave his support, although Kidd (1913) with- 

 out stating his reasons assumes it may be dismissed. 



At all events, the teratomata have afforded the most interesting cases, 

 neurologically speaking, although as yet no striking features in the clin- 

 ical syndromy seem to set them off from other types of tumors, either 

 as regards the metabolic disturbances, which might have been supposed to 

 be present, or the neighborhood syndromes. This matter has not as yet 

 been sufficiently analyzed in terms of increased or diminished functional 

 capacity. The chief recorded cases of teratomata are those of Weigert, 

 Gauderer, Coats, Falkson, Gutzeit, Neumann, Hueter, v. Frankl-Hochwart, 

 Bailey and Jelliffe, Hymans, Takeya, Fukuo, Odermatt and Boehm. 

 The pineal syndrome observed in most of these eases is considered 

 elsewhere. 



Carcinomata are recorded by Massot, Horrax, Forster, Daly, Hempel. 



Mixed and Compound Tumors. Other tumors have been described 

 also: Ependymal Neuroglioma (Pappenheimer) ; Chorio-epithelioma 

 (Askanazy) ; Adenomata (Meyer) ; Lipoma (Hertz) ; Sarcomata (most 

 numerous), (Nothnagel, v. Hoesselin, Turner, Kwy, Ogle, Konig, M. 

 Neumann, Oestreich Slawyk, Friedreich, Hart). 



II. Functional Pathology of Pineal 



Turning now from a more formal and statistical type of museum 

 neurology, the functional pathology of the pineal claims attention. Here 

 facts, speculations and dreams are still inextricably bound together. 

 Laignel-Lavastine, in his masterly study on the Internal Secretions and 

 Neurology (1919), has emphasized this necessity and the situation has 

 not radically altered since then. Following the example set by this stu- 

 dent of endoerinological problems, a graded series of observations passing 

 from the more capable of substantiation in the present stage of our igno- 

 rance to those as yet only guessed at by adventurous speculations may 

 be recorded. 



In the clinical section attention has been called to the striking correla- 

 tion between involvement of the pineal, in early years (chiefly teratomata), 

 and altered activity of the gonadal system, resulting in an early develop- 

 ment of the primary and secondary sex characters. 



Pellizzi gave the impetus to the generalization of a relation of the 

 pineal and macrogenitosomia and the experimental work inaugurated by 

 Foa (1912) and Sarteschi (1910) in Pellizzi's clinic would tend to 

 support the general hypothesis, even though there are many conflicting 

 observations, attention to which has already been called in the physiological 

 discussion. 



