SMITH ELY JELLIFFE 



1896 Gutzeit * 

 1899 Oestreich 



1899 Ogle 

 1903 Holzhauer 



1909 Frankl-Hochwart 



1910 Raymond and Claude 



1911 Bailey and Jelliffe 

 1913 Goldzieher 



1913 Hijmans 

 1913 Ta'keya 

 1915 Odermatt 

 1917 Boehm 



Teratoma 



Psammosarcoma 



Alveosarcoma . . 

 Alveosarcoraa . . 



Teratoma 



Glioma . 



Teratoma . . 12 



Angioblastosar- 



coma 



Teratoma .... 

 Teratoma .... 

 Teratoma .... 

 Teratoma 



7% yrs. Early development of pubes. 

 4 ' " Abnormal development of penis. 



Genital hair. 

 6 " Early genital hair, and mental 



development. 

 4 " Genital development. Long 



bone development. 

 Large development. Hairy. 



Genitals, -f- -f- Voice. 

 Adiposis, hairy, mentally pre- 

 cocious. 



Adiposis, large, early mental 

 development. 



5% 

 10 



16 " Hair and genital development. 



8 " Hair and genital development. 

 10 " Hair and genital development. 



9 " Hair and genital development. 

 914 " Hair, genital, voice and mental 



precocity. 



The cases of precocious puberty from gonadal tumors, that are 

 markedly modified by simple removal of the tumors possibly remain out- 

 side of the just emphasized caution. Askanazy has stressed this point in 

 his criticism of Marburg's generalization concerning the pathology of 

 pineal tumors and sexual precocity, although leaning in part to support 

 his argument on the old and we believe faulty deduction, which Berblinger 

 also emphasizes, that the pineal reaches its maximum functional capacity 

 at the age of seven. Krabbe's observations negative this view distinctly, 

 and furthermore he has shown that between the eighth and fourteenth 

 year a particular type of cell with basophil granules is a prominent 

 feature of pineal histology, and secretory cells as described by Krabbe, 

 Yigier, Uemnra (1917), and Nicholas are found apparently functionally 

 active at sixty (Uemura, Berblinger, v. Gierke, Schlesinger, Krabbe). 

 Askanazy lays weight upon the ontogenetic nature of this early sexual 

 precocity and since teratomata have given the chief evidences, speaks of the 

 fetal factors involved in this early sexual maturity. Inasmuch as distinctly 

 non-teratomatous and non-fetal pineal tumors are accompanied by the 

 gonadal activities these still need an explanation not furnished by As- 

 kanazy's hypothesis. Furthermore the histological study of the gonads 

 has almost been nil in these cases. 



The final conclusion of the matter may be stated that for the present 

 it may be assumed that Pellizzi's syndrome of macrogenitosomia may 

 be related to increased rather than to diminished activity of the pineal 

 gland. 



As with the pituitary so also with the pineal, lipoid or pigment 

 material is found in abundance. The fuchsinophil cells of Sarteschi are 

 very pronounced and it may be that lipoid substances enter into the 

 cycle of conversion products, not as waste pigment products, as has been 



