PHYSIOLOGY AND EXPERIMENTAL PATHOLOGY 109 



The temperature fall does not occur during the early hours of the 

 experiment if Biedl's dislocation method is employed. He says that 

 the temperature begins to drop about 48 hours before death at the time 

 when asthenia appears. There is a gradual reduction until just before 

 death when the fall becomes more abrupt (Hultgren and Andersson). 



Schwartz found a decrease in the metabolism after double epinephrec- 

 tomy. Gradinescu determined the oxygen and carbon dioxid exchange and 

 likewise found a decrease. The results of the latter are illustrated by 

 results taken from his table : 



RESPIRATORY EXCHANGE IN DECAPSULATED ANIMALS (GRADINESCU). 



By the use of the calorimeter Gradinescu determined the amount of 

 heat production in enpinephrectomized animals. 



HEAT PRODUCTION AFTER DOUBLE EPINEPHRECTOMY. (AFTER GRADINESCU.) 



