110 FKAKK A. HAKTMAN 



The after-effects of chloroform were determined so that it could be 

 taken into account following the operation. Excerpts from his table are 

 given. There comes a time when there is a reduction in the amount of 

 heat produced as would be expected from the subnormal temperature which 

 develops. Muscular asthenia is no doubt an important factor in producing 

 this condition. 



It is also to be noted that those animals which show a decided reduc- 

 tion in heat production after the operation live but a few hours. On 

 the other hand, animals which survive for days, do not present, marked 

 reduction until a few hours before death. 



Gradinescu's results have recently been confirmed by Aub, Forman 

 and Bright. 



Hypoglycemia. A further indication of metabolic disturbance is the 

 lowering of the sugar content of the blood. This reduction is not due to 

 operative shock because animals similarly treated but without excision 

 of the suprarenals do not show it (Forges). An example of the blood 

 sugar decrease is seen in the decapsulated dog of Bierry and Malloizel. 

 Before the operation the sugar content was 1.2 gm. to 1000 gm. of blood. 

 After excision of the capsules it had fallen, to 0. 8 gm. 



Experimental glycosurias and hyperglycemias are not so readily pro- 

 duced in decapsulated animals as in normals. Mayer (6) found that 

 piqure does not produce glycosuria in dogs and rabbits which lack the 

 suprarenals. Gautrelet and Thomas (c) failed to cause glycosuria by stim- 

 ulation of the splanchnic ne<rves in decapsulated animals. Epinephrin pro- 

 duced a smaller increase in the blood sugar than normal. The resulting 

 glycosuria was also smaller. Kahn(/) could not obtain CO or diuretin 

 hyperglycemia in a decapsulated rabbit, although he found that the liver 

 glycogen was normal. 



The reduction in the quantity of circulating carbohydrate might be 

 due to the smaller amount ingested as a result of decreased appetite. If 

 Schwartz's observation is correct it seems that there is less glycogen 

 stored in the body. He found glycogen absent in the liver of a decap- 

 sulated mouse. That would account for the failure of epinephrin and other 

 substances to cause the usual hyperglycemia. 



Changes in Respiration. One of the late symptoms of suprarenal in- 

 sufficiency is the progressive failure of the respiration. In such animals 

 pdypnea is not caused so easily by exposure to high temperatures. We 

 may cite as typical one of the experiments of Gautrelet and Thomas (d). 

 A rabbit whose respiratory rate was 135 per minute showed an increase 

 to 150 per minute immediately following double capsulectomy. Two 

 hours later this had been reduced to 100 per minute. At two and one-half 

 hours it had become 56 per minute. The surrounding temperature was 

 then raised to 42 C. but there was no increase in the rate, the rectal 

 temperature remaining at 33 C. However, elevation of the neighboring 



