PHYSIOLOGY AKD EXPERIMENTAL PATHOLOGY 111 



temperature to 49 C. for forty minutes raised the rectal temperature to 

 36 C. and increased the respiration to 130 per minute. The animal died 

 a few minutes later, death probably being hastened by the high tempera- 

 ture. 



Because morphin had been used during the operation in many of these 

 experiments we thought that it might possibly have been the cause of 

 the sluggish respiratory reaction. Therefore we 1 repeated the observa- 

 tion on a cat in which ether only was used as the anesthetic. One gland 

 was removed and a large proportion of the circulation to the other was 

 tied off. Before the operation the respirations numbered sixty to seventy- 

 five per minute. Nineteen hours afterward respirations had been reduced 

 to twenty-eight per minute. Forty-eight hours after, the pulse rate had 

 increased from 180 to 240 per minute. The cat could walk fairly well but 

 it chose to lie close to a hot radiator all of the time. Mental alertness was 

 lacking. 



Five days after the operation the rectal temperature was 34. 8 'C., the 

 heart beat was 150 per minute; it was determined by a stethoscope as 

 it was scarcely palpable. The gums were bloodless. The animal could 

 stand and walk about but was very weak. The respirations were now 

 twenty-four per minute. Placing it in a temperature of 40 C. for five 

 minutes produced no change in respiration, nor did exposure for the same 

 length of time at 44 C. produce any effect. Death occurred a few hours 

 later. 



Perhaps these respiratory effects are due to a partial paralysis of the 

 respiratory center. It is well known that epinephrin injections influence 

 the respiratory center. Yet Gautrelet and Thomas observed that the 

 respiratory acceleration which results from the injection of epinephrin, 

 was suppressed. 



Failure of respiration may be the cause of death from suprarenal 



| . insufficiency for just before the final collapse the respirations are greatly 



reduced. In the dog they may occur at the rate of five or six per minute, 



while in the rabbit the rate may become as slow as twenty per minute 



(Gautrelet and Thomas). 



Pigmentation. The pigmentation which appears in Addison's disease 

 fails to develop in most cases of suprarenal insufficiency. Earlier investiga- 

 tors describe many instances of pigmentation. In fact Brown-Sequard(a) 

 believed death from capsulatectomy to be due to an accumulation of pig- 

 ments in the blood. Among those who have described pigmentation are 

 Nothnagel(a) who noticed spots on the mucous membrane in three decap- 

 sulated animals out of 153, and Tizzoni who observed pigmentation in a 

 larger proportion of such animals. The development of tiny gray patches 

 in regions where the skin has been shaved has been described in suprarenal 



tfficiency by F. and S. Marino-Zuco. These findings have failed of 

 1 Unpublished results of Eisenberger and Hartman. 

 ' 



