PHYSIOLOGY AND EXPEKIMENTAL PATHOLOGY 121 



vaded by polymorphonuclear and endothelial leucocytes are not infre- 

 quent." 



The changes are said to be comparable to those produced in the cap- 

 sules by diphtheria toxin. Kolosko has described similar findings. 



Response of the Suprarenal in Pregnancy. During pregnancy both 

 the suprarenal cortex and medulla hypertrophy, the former increas- 

 ing much more than the latter (Guieysse(a), Stoerk and v. Haberer). 

 This certainly indicates an overactivity on the part of these glands. Ga- 

 bastou has found fat vacuoles constantly present in the suprarenal medulla 

 throughout pregnancy. This may also indicate excessive activity. 



Reaction to Cold. It is interesting to note the observation of Cra- 

 mer (&) that mice which resist exposure to cold possess suprarenals charged 

 well with epinephrin while the suprarenals of those that die from exposure 

 to cold are depicted of epinephrin. It has been shown that epinephrin 

 injections increase heat production ; therefore it is possible that epinephrin 

 is necessary to meet such an emergency. 



Effect of Cholesterol Feeding. Because of the suggestion from 

 some quarters that the suprarenal might be the seat of manufacture of 

 the lipoids of the body it is interesting to observe the effect of cholesterol 

 feeding on these glands. 



Bailey has found enlargement of the suprarenals in rabbits and guinea 

 pigs which were fed cholesterol daily. This appeared to be due to a storage 

 of anisotropic globules. Such accumulation occurred also in the liver 

 and medulla of the kidney. 



Influence of Diet on the Suprarenals. A scorbutic diet produces 

 congestion and enlargement of the suprarenals so that animals dying of 

 such fare possess glands double the normal weight. These changes were 

 studied by McCarrison(fr) in the guinea pig; they were brought about by 

 feeding crushed oats and autoclaved milk. The abnormal conditions 

 seen histologically were hemorrhagic infiltration and disintegration of 

 both cortical and medullary cells. These modifications have been con- 

 sidered as prescorbutic, since they have been found in animals exhibiting 

 no clinical evidences of scurvy during life. The epinephrin content of 

 such glands was less than one-half of that in normal glands (estimation 

 by Folin, Cannon and Denis' method). 



McCarrison previously found that pigeons, in which polyneuritis was 

 caused by feeding polished rice, developed enlarged suprarenals which 

 contained more epinephrin than normal. He found that by the addition 

 of accessory factors of "A" class in the form of fresh butter the epinephrin 

 content fails to increase. He concludes that lack of "A" class substances 

 caused the increased epinephrin in the polyneuritic pigeons. 



Effect of Inanition on the Suprarenals. The effect of inanition has 

 been carefully worked out by Jackson(c) (&) (m) (see Stewart (a) (c) (d) 

 for confirmation of Jackson's results) in the rat. He has found a variable 



