128 G. K STEWART 



Hoskins and McClure(a) saw no immediate fall in blood pressure after 

 ligating off the adrenal glands in dogs. The experiments of Dreyer, 

 Tscheboksaroff,(o.) Joseph and Meltzer, Asher and Elliott (c) proved con- 

 clusively that stimulation of the splanchnic nerve causes epinephrin to pass 

 from the corresponding suprarenal into the blood. The work of these inves- 

 tigators will be alluded to again in discussing the nervous mechanism con- 

 trolling the epinephrin secretion. Although not directly concerned with 

 the question, whether the glands are constantly giving off epinephrin, still 

 less with the question of the magnitude of the output, the demonstration 



Fig. 1. Uterus tracings. At 86, Ringer's solution was replaced by serum from 

 dog's suprarenal vein blood; at 87 by sediment from the blood (mainly corpuscles) ; 

 at 88, by the defibrinated blood. All the blood specimens were diluted with 14 volumes 

 of Ringer's solution before application to the segment. The tone-increasing action of 

 the serum was much greater than that of the sediment, the blood being intermediate. 

 Intestine tracings showed that the specimens occupied the same relative position as 

 regards the amount of inhibition, the sediment causing a very slight effect. Time 

 marked in half minutes, as in all the figures unless otherwise stated. (Reduced to 

 one-half.) (After Stewart and Rogoff, J. Pharm. & Exper. Therap.) 



that the suprarenal medulla is under the control of secretory nerves in- 

 creased the probability that a physiological output occurs. Tscheboksaroff 

 remarked indeed that the reaction on which he as well as Dreyer relied 

 (the rise of pressure produced by injecting intravenously into a dog a 

 given quantity of suprarenal vein blood from another dog) was much di- 

 minished by division of the splanchnic, indicating that some epinephrin 

 was being given off with intact splanchnic nerves in the absence of artificial 

 stimulation. 



Trendelenburg(a) (&) using the frog perfusion method (Laewen prep- 

 aration) found concentrations of epinephrin in the suprarenal vein blood 

 of cats varying from 1:360,000 to 1:1,000,000. O'Connor(a) (&), also 

 working with the frog perfusion method, showed that in the rabbit, after 

 section of the splanchnics, the epinephrin secretion of the suprarenals is 



