SIGNIFICANCE OF THE SUPRAKENAL GLANDS 143 



flow through the suprarenals and without quantitative determinations of 

 the amount of epinephrin liberated per unit of time, were not suitable for 

 testing the influence of afferent nerves. Up to the present, however 

 probable it may seem that the epinephrin-secreting mechanism can be 

 affected reflexly, no experimental demonstration that this occurs has been 

 given. 



It is the same with asphyxia. Anrep(fr) (1912) stated that he obtained 

 with asphyxia reactions on the denervated limb similar to those elicited by 



Fig. 14. Blood pressure tracing from a cat/ Asphyxia began at 22, stopped at 24. 

 Cava pocket closed to collect suprarenal blood at 23, opened at 25. 26, control pocket 

 experiment without asphyxia. The rise of pressure on opening the pocket is somewhat 

 greater in the. control experiment, corresponding to the somewhat longer time during 

 which it was kept closed. If asphyxia had stimulated the output of epinephrin the 

 rise in the asphyxia experiment would have been greater. Line of zero pressure moved 

 up 45 mm. (After Stewart and Rogoff, J. Pliarm. & Exper. Therap.) 



stimulation of sensory nerves, and he interpreted them in the same way, as 

 indicating an augmented output of epinephrin during asphyxia. Pearl- 

 man and Vincent have been unable to confirm v. Anrep's observations. 

 They saw no influence of asphyxia upon the denervated limb reaction, 

 which, in any case, for the reason already mentioned, could not be ac- 

 cepted as evidence of a quantitative increase in the epinephrin output. 

 The same is true of the observations of Cannon and Hoskins with the 

 catheter method. Stewart and Kogoff (a) (1916-17), using a direct quanti- 

 tative method (assay of suprarenal vein blood on rabbit's segments (Figs. 

 12 and 13)), were unable to demonstrate any definite effect of asphyxia 

 upon the rate of output, Nor were they successful with the method of 



