208 



E. G. HOSKINS 



In man, 'according to Kosencw (1918) intramuscular injections of 

 epinephrin characteristically result in an augmented volume of the fore- 



arm. 



From a teleological point of view, it is interesting that doses of epi- 

 nephrin of the magnitude obtainable by stimulation of the suprarenal 

 glands have the effect of diverting the blood in the extra-splanchnic area 



Fig. 7. Graph showing the effects of epinephrin upon venous outflow from leg of 

 a dog. Dose, 0.5 c.e. 1:100,000 solution, by vein. The peroneal nerve was cut four 

 days before and the sciatic previous to the beginning of the experiment. The upper 

 line represents arterial blood pressure; the second line time at 5 second intervals; the 

 third line, outflow of blood by drops; fourth line, signal. (After Gruber, Am. J. 

 Physiol.) 



from the skin to the skeletal muscle. This has aii obvious bearing upon the 

 "emergency theory" of suprarenal function. 



Effects on the Circulation of the Liver. The first important study 

 of the effects of epinephrin upon the circulation in the liver was reported 

 by Schmid (1909). A Stromuhr was inserted in the portal vein. It 

 was found that immediately following the injection of epinephrin the 

 volume of the portal blood-stream began to decrease, reaching its lowest 

 point synchronously with the maximum rise of blood-pressure, A second 



