220 



R. G. HOSKINS 



EFFECTS OF ADRENIN IN THE SMALL INTESTINE 



* Excluding one case of very low irritability. 



the first part of the reaction. There was no very definite correlation be- 

 tween the dosage and the reaction. In some animals smaller quantities 

 caused contraction, which was succeeded by dilatation as the dosage in- 

 creased. In other animals; however, the reaction remained constant except 

 as to degree, whatever quantity was injected. The range of doses investi- 

 gated was about the same as that employed by Hartman and McPhedran. 

 The threshold of reaction in the intestine was found in general to be about 

 the same as that of blood-pressure. There was no constant relation, how- 

 ever, between blood-pressure and intestinal volume changes. The volume 

 changes usually persisted after the blood-pressure returned to normal, 

 indicating reflex compensatory adjustments among various organs. An 

 after-dilatation of the intestine was frequently noted when the primary 

 epinephrin effect had worn off. 



In view of the fact that other investigators had reported that epi- 

 nephrin may check the blood flow in the portal veins, the question arose to 



