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glomerulosa from a case of burns. The patient was an old man who was 

 badly burned about the legs ; first, second, and third degree burns were 

 present. He lived nine days after the accident. Both suprarenals were 

 swollen and hemorrhagic. There was extensive recent thrombosis of the 

 veins, and microscopically there was focal exhaustion of the cortical lipoid 

 with extensive necrosis and hemorrhage into both cortex and medulla. 

 The photograph shows hemorrhage into a portion of the glomerulosa with 

 blood corpuscles within the columns of cells. Hemorrhage may also occur 

 in the hemorrhagic diatheses and in leucemia. has also been described in 

 general venous stasis due to 

 cardiac disease. 



Amyloid degeneration is as 

 common in the suprarenals as 

 in the spleen and liver. It 

 is produced by the same causes, 

 viz., chronic suppuration, tu- 

 berculosis and syphilis. As 

 in the liver, the amyloid is 

 deposited in the walls of the 

 sinusoids. It is more marked 

 in the fasciculata but may be 

 found throughout the cortex 

 and in the medulla ; in the cor- 

 tex the parenchymal cells are 

 gradually compressed by the 

 amyloid material. 



Parenchymatous degenera- 

 tion is common but often diffi- 

 cult to differentiate from postmortem change. In 1909 Oberndorfer de- 

 scribed peculiar hyaline or colloid droplets in the medulla of suprarenals of 

 twelve cases, ten of which were from acute infectious disease. He is in con- 

 siderable doubt as to the interpretation of these droplets or granules and 

 discusses whether they are of the nature of Russell's bodies, which they 

 resemble closely, or are phagocyted red blood cells. These droplets vary in 

 size from larger than the nucleus to quite small granules. We have seen 

 them very commonly in influenza cases, but they are not confined to 

 influenza as we have found them in pyemia, in bacillary dysentery and 

 other acute bacterial infections. They have not been often noted, but if 

 searched for in well fixed material they are not difficult to find. In 

 hematoxylin-eosin staining they take a rose-red color, and like the Russell 

 granulations, they are fuchsinophil. But they are best demonstrated by 

 Mallory's phosphotungstic acid hematoxylin or Mallory's anilin blue con- 

 nective tissue stain. With the former they are usually a deep blue: the 

 latter stain brings out clearly that they are not homogeneous structures 



Fig. 4. Hemorrhage into the zona glomeru- 

 losa from a case of fatal burns. 



