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J. J. MACKENZIE 



photographs of suprarenals from 

 influenza cases. The cells of the 

 cortex containing lipoid appear 

 black in the photograph. 



Landau and McNee have 

 determined quantitatively the 

 amount of cholesterol and cho- 

 lesterol esters in a large series 

 of cases and their conclusions 

 are that the total cholesterol con- 

 tent of the human suprarenal ap- 

 pears diminished an phthisis and 

 other infectious diseases and in 

 many neoplasms but that in in- 

 anition and pedatrophy it. is 

 high and in circulatory disturb- 

 ances (contracted kidneys, ar- 

 teriosclerotics, cardiopathics) it 

 is very markedly increased. 

 These variations are conditioned 



chiefly by variations in the cholesterol esters whilst the free cholesterol only 

 slowly follows the changes in 

 the cholesterol esters and is not 

 affected by the momentary vari- 

 ations in them. 



The degree of chromaphil 

 staining of the suprarenal me- 

 dulla, the amount of epinephrin 

 and its variation in infectious 

 diseases have also been subjects 

 of careful study by a number of 

 observers. Elliott's(^) quanti- 

 tative observations were among 

 the first. IFe gives the normal 

 load of epinophrin at about 4.5 

 ing. per gland in the adult and 

 be shows that the amount is les- 

 sened in many acute febrile con- 

 ditions but could find no proof 

 that it was increased above nor- 

 mal in any disease. Loeschke 

 studied 100 eases for cbrom re- 

 action and epiiiephriu content and found a reduction or complete absence 

 in all acute infections. Ingier and Scbmorl found it diminished in acute 



Fig. 7. Section of suprarenal from a case 

 of influenza fourteen days' duration; double 

 empyema, collapse of both lungs. Frozen 

 section, stained scarlet and hematoxylin. The 

 black areas in cortex are focal areas of lipoid. 



Fig. 8. Section of suprarenal from a case 

 of influenzal bronchopneumonia of twenty-five 

 days' duration ; frozen section, stained scarlet 

 red and hematoxylin. The black areas in cor- 

 tex are focal areas of lipoid. 



