274 



J. J. MACKENZIE 



In turners of the pituitary, especially in acromegaly, occasional ob- 

 servations indicate that suprarenal change occurs. Delille states that 

 hypertrophy of the suprarenals is often found in 'acromegalics. Fischer 

 found in two cases enormous hypertrophy of the suprarenals, in one 

 case this organ being five times as large as normal, and he believes that 

 there was true excess of suprarenal tissue beyond what would be accounted 

 for by the general splanchnomegaly. He quotes Stadelmann(&) as finding 

 cystic suprarenals in an acromegalic but a reference to Stadelmann's 



article shows that the change 

 was of the usual postmortem 

 character. 



Fig. 9 is a photograph of an 

 interesting suprarenal from a 

 case which died suddenly in the 

 wards of the Toronto General 

 Hospital, and illustrates a pos- 

 sible relationship between pitui- 

 tary and suprarenal. The pa- 

 tient was a man, aged 28, who 

 entered the hospital with symp- 

 toms of brain tumor and died 

 suddenly. The man presented 

 no abnormality except that the 

 pubic hair was sparse and trans- 



Fiji. 0. Photograph of a portion of the left 

 suprarenal from a case of cystic tumor of the 

 hypophysis, stained with scarlet red and hema- 

 toxvlin. 



verse in arrangement. The hair 

 on the face and axillae was also 

 sparse. He was married and 

 the father of several children. 



His blood pressure was 110, S. and 85, D. The necropsy revealed a large 

 cystic tumor of the hypophysis. The thymus was present and weighed 

 1<S grammes but there was no evident hyperplasia of the lymphadenoid 

 apparatus. The suprarenals were small and the section shows a strikingly 

 narrow cortex heavily loaded with lipoid and a hypertrophied medulla. 

 It would seem as if in this case the relative proportions of the cortex and 

 medulla had been influenced either by the degenerative changes in the 

 hypophysis or by the condition of partial status thymolymphaticus. 



In status thymolymphaticus, as indicated in the discussion of Addi- 

 son's disease, there is a special tendency for tuberculous infection to invade 

 the suprarenal glands. 



In diabetes no special morphological change in the suprarenals has 

 been described. 



