PUBEKTAS PRECOX 351 



may be presumed that they exist. Gushing suggests "the glandular ele- 

 ment which is responsible for the physical changes of puberty, differs from 

 that which concerns ovulation and reproduction, and may possibly be a 

 function of specific interstitial cells." 



Summary 



We have then reported cases of pubertas precox associated with tumors 

 (usually teratomata) of the pineal, hyperplasia of the pituitary (as shown 

 by enlarged sella turcica in rontgeoiograms) and tumors of the gonads. 

 We may presume to theorize then that the growth in testes and ovaries acts 

 as a stimulant to the interstitial cells and seminiferous tubules: that 

 changes in the anterior pituitary body and pineal send stimulating influ- 

 ences to the suprarenal body and it in turn sends acceleratory influences 

 to the gonads. 



