Clinical Syndromes Due to 

 Suprarenal Diseases 



Virilismus 



HENRY D. JUMP 



PHILADELPHIA 



Virilismus may be defined as a condition occurring in women and girls 

 manifested by hairiness of the face, body and extremities, and accom- 

 panied by somatic and genital changes resembling the male. There is a 

 development of maleness or male characteristics at the expense of the 

 female. 



Pre-Adolescent Group 



j.n the cases occurring before the age of puberty there is a premature 

 development of the genitalia with pubic hair of the male type, often an 

 enlargement of the clitoris and lack of development of the breasts. The 

 body grows out of proportion to the age. The most of the cases are obese : 

 some are muscular and strong beyond their years, walking earlier than 

 normal and showing unusual strength. The majority are mentally dull but 

 a few are bright. The voice develops a deep tone. The skin is 

 rough and often the seat of acne: pigmentation is occasionally present 

 but there is never the bronzing, characteristic of Addison's disease. These 

 children never menstruate. All of the reported cases died before the six- 

 teenth year. They are poor surgical risks, several having succumbed to 

 minor surgical operations. Ritchie's case died three days after an oste- 

 otomy: O. Richard's cases died shortly after tapping for ascites. 



The following case reported by Jump, Beates and Babcock is typical 

 of this class. The patient was a girl who died at seven and a half years. 

 She was the larger one of twins, weighing six pounds at birth. She failed 

 to grow normally during the first six months of her life, because of an in- 

 ability to regulate her artificial feeding. When the proper mixture was 

 found she developed rapidly, gaining eight pounds in two months. Her 

 growth continued rapidly until finally she was fifty-three inches tall and 

 weighed about ninety pounds. Her general form was more masculine than 

 feminine and she developed great strength. She was not obese. Hair was 

 first noted on her legs and pubes and in the axilla when she was one year 

 old. At the seventh year it appeared on her arms, lip and chin. At the 

 time of her death the hair of the scalp was long, curly and moderately 



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