498 



V. D. LESPINASSE 



In the vitreous degeneracy, the cytoplasm is first involved. Later on, 

 the nucleus changes and disappears before the cytoplasm. All varieties of 

 degeneration are observed and they follow one another or sometimes asso- 

 ciate with one another to make degenerate, bastard types. 



(B) Cells "en mitose" are the seat of many alterations, but these alter- 

 ations are never observed in the stages anterior to the "plague equatoriale." 



Degenerate "mitoses" are for the most part asymmetrical. 



Sometimes normal "chromosome," and sometimes those of unusual, 

 shape and irregular form, distribute themselves in uneven number in 

 two nucleus threads. At other times these chromosomes do not show 



Fig. 5. Low power photomicrograph of a guinea pig testicle whose nerve and 

 blood supply was completely severed but the organ allowed to remain in the scrotum; 

 note that the spermatogenic tubules have disappeared and the organ is a mass of 

 interstitial cells. (A true iso graft.) 



any regularity in their distribution. They can be found distributed here 

 and there in the cytoplasm. 



The weaving shows us similar anomalies. The vanishing fibers of cer- 

 tain cells thicken on certain others or take wandering directions. The 

 right half of a fusion does not maintain the same shape as the left half. 

 If the upper segment of a fusion is normal, its lower segment may be al- 

 together wanting. Other times, this segment is only truncated; it is 

 terminated on one surface, cut off at right angles ; its cut extremity 

 is entirely missing. 



One often notes the absence of central corpuscles or their transforma- 

 tion into voluminous bodies of spherical form and acidophile reaction. 



It happens sometimes that the nuclei issuing from the "mitose" re- 

 form themselves without the cytoplasm participating in the division; 

 a binucleated cell results from this anomaly. Each of these nuclei so 



