TESTICLE AS GLAND OE INTERNAL SECRETION 511 



r*t ADRENAL * 17 



CONTROL *J6 



Figs. 22-23. Birds 17 ami 16 are two Rhode Island Red Cockerels. When one month 

 old, we transplanted into bird 17 two adrenal glands, placing them in the muscles of 

 the breast. Note the precocious sexual development as compared with the normal bird 

 No. 16. 



At the time these photos were taken, the normal bird was the only one 

 that was crowing and evincing- any sexual libido. 



Thus in this series of birds we have produced every state of eunuchism 

 anil eunuchoidism and show that the appearance and development, of the 

 secondary sexual characteristics are in direct relation to the testicular 

 volume of the individual. 



Retarded Puberty 



With careful history taking, one can detect many cases of slight re- 

 tardation of puberty. These patients rarely come to the physician except 

 late in life when their congenitally poorly developed interstitial tissues 

 have broken down earlier than normal, and they come seeking relief for 

 sexual deficiencies. These cases of hormonic deficiency constitute a large 

 percentage of the cases of impotency that one sees clinically. The marked 

 congenital type of sexual deficiency is associated with severe lesions of the 

 pituitary gland, the thyroid, and also is a part of a general bodily defi- 

 ciency called infantilism. 



The commonest and most marked clinical pictures of retarded puberty 

 and hypogenital development in the child are associated with destructive 

 lesions of the anterior lobe of the pituitary. If these destructive lesions 

 ocdur during infancy they cause cessation of development of the testicle, 

 and genitalia in general, and also the secondary sex characteristics do not 

 develop. If these lesions occur in the individual later in life they will 



