PATHOLOGY OF THE OVARIES AS ENDOCRIN ORGAN'S 607 



the cyst and is not recognizable as normal ovarian tissue. Papillomatous 

 growth and malignant change are not infrequent. 



Carcinoma arising from these structures varies from carcinoma in 

 other organs by the fact that one may find glandular forms, tubular forms, 

 cystic and solid forms of the new growth in the same* mass. Carcinoma 

 is usually bilateral. Ovarian function probably ceases early in the dis- 

 ease. 



Adenomata of the ovaries are fairly common, usually solid, frequently 

 of large dimensions, and not infrequently contain malignant characters, 

 though such may not be detectable with the microscope. These probably 

 also arise from the fetal structures of the ovary. It is quite the common 

 new growth of the ovary in childhood, due, it is thought, to faulty develop- 

 ment. There is usually no normal ovarian tissue to be found in such 

 cases. 



Dermoids and teratomata are of common occurrence in the ovary. 

 Whether these are similar in origin and nature is still a disputed point. 

 In the case of small dermoids normal ovarian function may be seen going 

 on in the immediate vicinity of the growth, but I have never seen this 

 occur in cases of teratomata of the ovary. The teratomata contain the 

 three embryonic layers well developed, though perhaps not equally. In 

 the dermoids the ectoblastic layer predominates so as to mask the other 

 layers, though it is stated by many that careful search will always bring 

 the three layers to light, thus placing these two types of new growth in 

 the same class. 



Connective tissue growths of the ovary are rare, as are also myomatous 

 tumors. 



Changes in the Ovary Incident to Defective 

 Uterine Pregnancy 



In cases of pregnancy in which the ovum or placenta has undergone 

 pathological changes certain morphological changes of the ovary are fre- 

 quently met. 



In cases of hydatiform cystic disease of the placenta and in cases 

 of chorioepithelioma one finds, not only all the changes incident to a nor- 

 mal pregnancy but it is frequently found that nearly all the Graafian 

 follicles, whether mature or immature, become cystic and the periphery 

 of these cysts is made up of large oval or polygonal cells in which fatty 

 droplets, deeply staining with Sudan III, are readily seen. As a rule 

 such a condition of excessive secretory function is merely a temporary 

 one, subsiding with the removal of the diseased process in the uterus. 

 Those follicles whose peripheral cells have undergone such secretory ac- 

 tivity are usually obliterated and their ova undergo destruction. This 



