INFANTILISM 



867 



discussion may occur with or without clinically visible disturbance of the 

 genital organs (dysgenitalism) , Bicdel in 32 cases of hypophysial adi- 



Fig. 7. Rear view of same patient. (Ibidem, page 334.) 



posity found only 12 with genital atrophy. An extreme case of obesity 

 in a child has lately been illustrated by Talbot. 



Multiglandular Infantilism 



Due to the interdependence of the individual glands of the endocrin 

 cycle primary anatomical lesions of one member will also cause others to 

 suffer to a certain degree. In myxedema, for instance, athyreosis is ad- 

 mittedly the principal but not the exclusive pathogenetic factor, inas- 

 much as the chromaphil tissue, and especially the germinative glands, 

 are more or less involved. In fact, according to Sante de Sanctis, the 

 whole hormonopoietic apparatus participates. In hypopituitarism we find 

 dysgenitalism particularly. These disturbances, however, are secondary 

 and only functional, and with the restoration of the primarily affected 



