INFANTILISM 877 



endocrin secretion of the pancreas with diabetes. Pancreas extract was 

 administered without any result. The autopsy revealed, in addition to 

 changes in the pancreas, a pronounced hypophysial and thyroid affection 

 and hepatic cirrhosis, justifying, in the opinion of the writer, the classifi- 

 cation of the case among the pluriglandular diseases. 



Amenta described pancreatic diabetes with "pancreatic infantilism 7 ' 

 in a boy 8 years old weighing 7400 grams who from the end of the first 

 year had suffered from pancreatic diabetes. 



M. Landoli reported a case of infantilism of gastric origin. The 

 patient, aged 20 years, was the size of a ten-year-old boy; the stunted 

 growth was caused by gastrosuccorrhea of long duration. 



Varieties of Dystrophic Infantilism in Hepatic and Renal Diseases. 

 Finlayson reports the case of a twenty-three-year-old man who suffered 

 from biliary cirrhosis. His weight was only 35% kilos. His brother, 

 aged nineteen years, likewise suffered from this hepatic affection and 

 had a weight of 31 kilos. Hasenclever published three cases of infantilism 

 in one family associated with liver cirrhosis ; and similar observations are 

 reported by Hutinel, Taylor, Gilbert and Fournier, Lereboullet, Cautley, 

 Falta (observation No. 60). 



Otto May speaks of renal infantilism in congenital or early acquired 

 chronic interstitial nephritis and in connection with diabetes insipidus. 

 Observations pertaining to this category of infantilism have been contrib- 

 uted by Miller and Parson, Fletcher, Naish, Miller, Sutherland, Weber, 

 Cherry, Porter, Holt and others. That infantilism associated with diabetes 

 insipidus may be of hypophysial origin appears certain in the light of our 

 knowledge of the relation that exists between the pituitary body and poly- 

 uria. (Case of Antonelli.) 



Infantilism Resulting from Brain Lesions; Traumas. Lesions of the 

 brain, as encephalitis or microcephaly, porencephaly and other develop- 

 mental cerebral abnormalities, embraced in the clinical group of cerebral 

 infantile paralysis, and also progressive paralysis in early life may project 

 themselves somatically in a defective general development with reduced 

 longitudinal growth and body weight through the interference with the 

 normal influence of the central nervous system upon the bones, musculature 

 and the various glands and organs. Indeed a striking parallelism exists 

 in idiots between the weight of the brain and that of the organs and be- 

 tween the weight of the brain and the duration of life, as established by 

 H. Vogt's investigations. The reduction in size of microsephalic indi- 

 viduals may bring the body within the compass of the small brain, so that 

 the smallness of the skull would not in itself attract our attention. In 

 many idiots also the function of ossification was found to be irregular. 

 Interesting data on the growth in length and volume of idiotic children 

 are contributed by Dollinger in his recent publication on Idiocy. 



In the, experience of Anton, traumas also, and especially those due to 



