884 



WALTER TIMME 



in one instance and at another time to a child with status thymico- 

 lymphaticus ? Why should the ablation, by surgery, of the thyroid, fre- 

 quently be followed by hypertrophy of the pituitary, but occasionally not 

 at all? Following this reasoning as applied to whole families through 

 several generations, why should union of two endocrinopaths result in 

 many diverse types of endocrin disturbance through successive generations, 

 whose various members seldom transmit the identical disease entity they 

 themselves possess ? 



An illustrative chart of endocrinopathic heredity is here given. 



Examining this chart, we see that through four generations, beginning 

 with the union of a moderate giant and a diabetic, the greatest diversity 



Parents 



F1 



F3 



_ (j) (QNonnal ( 



18 19 20 21 22 23 24 Females \%Abnamial ten<?ency\ 



l< 



CHART SHOWING ENDOCRINOPATHIC INHERITANCE 



1. 

 2. 

 6. 



9. 

 11. 

 12. 



Giant, 



Diabetic 



Dyspituitaric 



Exophthalmic Goiter 



Harelip 



Dyspituitaric 



14. Congenital Blindness 



15. Moderate Giant 



16. Giant 



18. Osteomalacia and Dwarf 



21. Hyperpituitaric 



of endocrinopathic inheritance is manifest. Gigantism, exophthalmic 

 goiter, dwarfism, hypothyroid state with infantilism, and dyspituitarism 

 are all encountered. Is it not reasonable to suppose that those states repre- 

 sent the attempt of the individual to counterbalance the odds that have been 

 laid against him in the transmission of a condition which if persistently 

 transmitted, would bring the stock to an end ? It is this struggle against 

 a stock deficiency that brings latent possibilities and potentialities to the 

 fore, and makes for the survival of the individual. So must we have indi- 

 vidual pluriglandular disturbances as well as stock pluriglandular mani- 

 festations. And so arise the traits and reactions and adjustments of each 

 unit of the family, making of such unit an individual different from al| 

 others (Timme (a,), 1916). 



Noel Paton says, a When studying the action of the testes and thymus 

 on growth, I found that one guinea-pig in my series, after removal of the 



