270 A. I. RINGER AND EMIL J. BAUMANN 



CH 3 CH 3 



I +H 2 | 



CH > CH 2 



1 1 Reduction | 



CH CH 2 



I I 



CHO CHO 



Crotonic Butyl Aldehyde 

 Aldehyde 



CH 3 CH 3 CH 3 



CH 2 CH 2 CH 2 



CH 2 CH 2 CH 2 



CO 



CHO + Splitting off, CH Decarboxilation CH 



CH 3 of H 2 O || || 



Butyl aldehyde | , CH CH 



CO 



| CO CHO 



COOH | 



Pyruvic Acid COOH 



CH 3 CH 3 



CH 2 CH 2 . Unites with another molecule of pyruvic 



CH 2 4~ H 2 CH 2 > acid, and so on until the higher com- 



| Reduction | 

 CH CH 2 pounds are reached. 



M I 



CH CH 



CHO CHO 



Caproic 

 Aldehyde 



From the ahove we may see that fat formation can only take place in nor- 

 mal animals that have the power of splitting glucose, for the building stones, 

 acetalclehyde and pyruvic acid, are mainly products of glucose catabolism 

 In conditions of diabetes in which there is a loss in the individual's ability 

 to break down the glucose molecule, fat formation from carbohydrate must 

 be correspondingly reduced. This helps to account for the extreme and 

 rapid emaciation in severe diabetes. 



