644 



JOHN E. MUKLIN 



infant was not more active than the first wholly invalidates their con- 

 clusions. 



The dynamic effect of protein in the metabolism of an infant was first 

 proved by Rowland (&). Adding 4 grams of nutrose (containing 14.25 

 per cent nitrogen) to each of three previous feedings increased the metab- 

 olism of his first subject, three months of age, 10 per cent. Adding 30 

 grams to the food of his second child of 7 months raised the metabolism 



26 per cent 



TABLE 31 



DYNAMIC EFFECT OF PROTEIN (Howland) 



Murlin and Hoobler saw a similar effect from changing to a richer protein 

 formula the diet of an atrophic infant three months of age. The 

 nitrogen in the urine rose in response to the greater intake of protein 

 and the heat production was increased more than two calories per hour. 

 The child slept throughout, but made more frequent readjustment move- 

 ments after the high protein feeding. Hoobler (&) followed up this sub- 

 ject independently and demonstrated a much higher metabolism by feed- 

 ing progressively higher and higher protein formulas. The following 

 comparison of the periods on low and on high protein diets summarizes 

 his results on a single subject. 



TABLE 32 

 DYNAMIC EFFECT OF PROTEIN (Hoobler) 



The highest dynamic effect of milk protein ever recorded was obtained 

 on this child on the twelfth day of the special feedings when the amount of 

 protein (in the form of albumin-milk) in the 24 hours food was 43.3 grams 

 compared with 9.9 grams in the basal diet. The dynamic effect in ab- 

 solute terms was 108 calories for the 24 hours, or 42.4 per cent! 



The dynamic action of fat seems to be proved by the following obser- 

 vations made by Xiemann(a) on a normal, though at the time underweight, 



