EFFECTS OF CERTAIN DRUGS AND POISONS 769 



Protein Metabolism. After antipyrin the nitrogen excretion is not 

 much changed in man or in dogs. In fever it is often found reduced 

 (Miillcr). This effect may, however, be simulated by renal retention. 



Salicylates increase the elimination of nitrogen, as has been repeatedly 

 demonstrated. Goodbody, for example, found urea and ammonia both 

 increased. According to Wiley repeated ingestion of salicylate results 

 in some loss of weight and of nitrogen. 



Singer found both nitrogen and uric acid excretion increased after 

 acetyl-salicylic acid in rabbits. Denis (c) and many others have found 

 the uric acid excretion increased under salicylates. According to Fine 



<T.C. 



CM. 



rrn 



200 



CO 



37 



100 



T* 



A. 



** 



12. 



jr- 



Fig. 4. Effects of acetyl salicylic acid on patient with tuberculous abscess; 

 broken line, oxygen c.c. per minute; lighter horizontal line, carbon dioxid c.c. per 

 minute; heavier horizontal line, calories produced per minute; dotted line, calories 

 eliminated per minute; continuous curve, body temperature. Drug administered at 

 arrow. (H. G. Barbour, Arch. Int. Med., 1919, XXIV.) 



and Chace(&) this is due to increased permeability of the kidneys, for the 

 blood uric acid is lowered. 



Hanzlik has thoroughly reviewed the literature on salicylates. With 

 Scott and Reycraft he demonstrated an accumulation of urea in the blood 

 (associated with renal impairment and edema) after administration of 

 full therapeutic doses of sodium salicylate. 



Acetanilid in four to five gram doses increased the nitrogen metab- 

 olism of Kumagawa's dogs by over 30 per cent. Chittenden in normal 

 men found the nitrogen excretion unaltered, but the urea was diminished 

 by 10 to 20 per cent. Sulphates, phosphates, and chlorids were not 

 significantly altered. 



Quinin reduces the nitrogen metabolism definitely, as shown by Noor- 

 den and Zuntz and many others. Loewi found the percentage of urea 

 nitrogen slightly decreased. 



Reproduction and Growth. Riddle and Anderson have shown that 

 quinin fed to laying ring doves reduces the size of the eggs, the yolks 



